Pseudomonas aeruginosa PAO1 Gene: bioD

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ID: PA0504

Citations: [ Krell70 , Alexeev94 , Huang94 , Yang97 ]

Sequence Length: 687 bp / 228 AAs

Products: dethiobiotin synthase

Click on product name to see summaries, citations and other data about the gene product and its function.

Reactions Catalyzed by Enzymes:
CO₂ + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP

Pathways Involving Enzymes: biotin biosynthesis II

Gene-Reaction Schematic:

GO Terms:

Unification Links: PseudoCAP:PA0504

Gene Local Context (not to scale):

Transcription Unit:

Notes:

• A dashed baseline indicates that there is no high-quality evidence to confirm the extent of this transcription unit.
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References

Alexeev94: Alexeev D, Bury SM, Boys CW, Turner MA, Sawyer L, Ramsey AJ, Baxter HC, Baxter RL (1994). "Sequence and crystallization of Escherichia coli dethiobiotin synthetase, the penultimate enzyme of biotin biosynthesis." J Mol Biol 235(2);774-6. PMID: 8289297

Huang94: Huang W, Lindqvist Y, Schneider G, Gibson KJ, Flint D, Lorimer G (1994). "Crystal structure of an ATP-dependent carboxylase, dethiobiotin synthetase, at 1.65 A resolution." Structure 2(5);407-14. PMID: 8081756

Krell70: Krell K, Eisenberg MA (1970). "The purification and properties of dethiobiotin synthetase." J Biol Chem 245(24);6558-66. PMID: 4921568

Yang97: Yang G, Sandalova T, Lohman K, Lindqvist Y, Rendina AR (1997). "Active site mutants of Escherichia coli dethiobiotin synthetase: effects of mutations on enzyme catalytic and structural properties." Biochemistry 36(16);4751-60. PMID: 9125495