Pseudomonas aeruginosa PAO1 Gene: nrdA

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ID: PA1156

Citations: [ Torrents06 , Jordan96 , Stephens98 ]

Sequence Length: 2892 bp / 963 AAs

Products: NrdA, catalytic component of class Ia ribonucleotide reductase , subunit of ribonucleoside reductase

Click on product name to see summaries, citations and other data about the gene product and its function.

Reactions Catalyzed by Enzymes:
a 2'-deoxyribonucleoside diphosphate + an oxidized thioredoxin + H₂O + 2'-deoxyribonucleoside diphosphate = a ribonucleoside diphosphate + a reduced thioredoxin + ribonucleoside diphosphate

Gene-Reaction Schematic:

GO Terms:

Unification Links: PseudoCAP:PA1156

Gene Local Context (not to scale):

Transcription Unit:

Notes:

• A dashed baseline indicates that there is no high-quality evidence to confirm the extent of this transcription unit.
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References

Jordan96: Jordan A, Aragall E, Gibert I, Barbe J (1996). "Promoter identification and expression analysis of Salmonella typhimurium and Escherichia coli nrdEF operons encoding one of two class I ribonucleotide reductases present in both bacteria." Mol Microbiol 19(4);777-90. PMID: 8820648

Stephens98: Stephens RS, Kalman S, Lammel C, Fan J, Marathe R, Aravind L, Mitchell W, Olinger L, Tatusov RL, Zhao Q, Koonin EV, Davis RW (1998). "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Science 282(5389);754-9. PMID: 9784136

Torrents06: Torrents E, Westman M, Sahlin M, Sjoberg BM (2006). "Ribonucleotide reductase modularity: Atypical duplication of the ATP-cone domain in Pseudomonas aeruginosa." J Biol Chem 281(35);25287-96. PMID: 16829681